|
KMID : 1100220060050020033
|
|
Dementia and Neurocognitive Disorders
2006 Volume.5 No. 2 p.33 ~ p.36
|
|
|
Assessment of Cerebral Cortex Excitability Using Transcranial Magnetic Stimulation in Alzheimer’s Disease
|
|
Lim Jun-Seong
Paik Nam-Jong
Lee Jung-Seok
Kim Sang-Yun
|
|
|
Abstract
|
|
|
Background: Transcranial magnetic stimulation (TMS) was recently adopted as a technique to investigate subclinical disturbances in the motor cortex in patients with Alzheimer’s disease (AD). The aim of this study is to explore the motor cortex excitability and the state of inhibitory and facilitatory neuronal circuits in AD.
Methods: Resting motor threshold (RMT), short latency intracortical inhibition (SICI), short latency afferent inhibition (SAI), and intracortical facilitation (ICF) after paired pulse TMS were studied in AD patients and normal controls.
Results: The mean RMT was significantly lower in AD patients than in controls. The amounts of SICI and SAI were significantly smaller in AD patients than in normal controls. In contrast, ICF was significantly increased in AD patients.
Conclusions: By TMS procedures, we assessed the hyperexcitability of the motor cortex in AD. We found that inhibitory neuronal circuits were reduced and facilitatory neuronal circuits were increased in AD.
|
|
|
KEYWORD
|
|
|
Transcranial magnetic stimulation, Cerebral cortex excitability, Alzheimer’s disease
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|